IFNA antibody

Catalog No. ABIN2474115

This anti-IFNA antibody is a Mouse Monoclonal antibody detecting IFNA in WB and ELISA. Suitable for Chicken. This Primary Antibody has been cited in 3+ publications.

Quick Overview for IFNA antibody (ABIN2474115)

Target: IFNA (Interferon alpha (IFNA))

Reactivity: Chicken

Host: Mouse

Clonality: Monoclonal

Conjugate: This IFNA antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: UMCh3-IFNa

Product Details anti-IFNA Antibody

Specificity: This antibody recognizes chicken Interferon alpha (chIFN-alpha). The classification of mammalian cytokines with antiviral activity, is well documented as being either Type I Interferon (IFNI) or Type II Interferon (IFNII). This is not the case for avian IFNs however, even though IFN was first detected in the chicken. A growing number of functional studies indicate similarities between chicken IFN and mammalian IFNI, revealing the conservation of cysteine residues and the existence of around ten closely related intron-less IFN alpha genes. Further research has shown that chIFN-alpha genes are strongly expressed following viral infection of monocyte-derived macrophage and embryo fibroblasts and that recombinant chicken IFN acts as a potent antiviral agent. This antibody does not cross react with IFN beta or IFN gamma and does not neutralize chIFN-alpha.

Characteristics: Purified IgG

Purification: Purified

Immunogen: Recombinant chicken Interferon alpha.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

References for anti-IFNA antibody (ABIN2474115)

Sarmento, Afonso, Estevez, Wasilenko, Pantin-Jackwood: "Differential host gene expression in cells infected with highly pathogenic H5N1 avian influenza viruses." in: Veterinary immunology and immunopathology, Vol. 125, Issue 3-4, pp. 291-302, (2008) (PubMed).

Schwarz, Harlin, Ohnemus, Kaspers, Staeheli: "Synthesis of IFN-beta by virus-infected chicken embryo cells demonstrated with specific antisera and a new bioassay." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 24, Issue 3, pp. 179-84, (2004) (PubMed).

Staeheli, Puehler, Schneider, Göbel, Kaspers: "Cytokines of birds: conserved functions--a largely different look." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 21, Issue 12, pp. 993-1010, (2002) (PubMed).

Target Details for IFNA

Target: IFNA (Interferon alpha (IFNA))

Alternative Name: IFN alpha

Background: Synonyms: INTERFERON ALPHA

Gene ID: 396398

UniProt: P42165

Pathways: JAK-STAT Signaling, TLR Signaling, Hepatitis C, Inflammasome