Toxin A (AA 2123-2132) antibody

Details for Product No. ABIN2476899
Antigen
Epitope
AA 2123-2132
Reactivity
Clostridium difficile (C. difficile)
11
Host
Rabbit
9
2
Clonality
Polyclonal
Conjugate
Un-conjugated
1
Application
ELISA
11
6
Options
Immunogen Synthetic peptide corresponding to the amino acids 2123-2132 of the native molecule conjugated to Keyhole limpet Haemocyanin. Peptide sequence: CTIDGKKYYFN
Isotype IgG
Specificity This antibody is specific for Clostridium difficile Toxin A, a gram-positive motile bacterium which is the leading cause of diarrhoea in developed countries. The incidence of disease in humans varies greatly with age, spore density, and the administration of antibiotics. Toxin A (TcdA) is a large exotoxin which is an essential virulence factor for C. difficile infection. TcdA has a molecular weight of 308kD and is a glucosyltransferase, which irreversibly inactivates the Ras family of small GTPases to disrupt many important signalling pathways.
Characteristics Purified IgG
Purification Purified
Antigen
UniProt P16154
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 5.0 mg/mL
Product cited in: Voth, Ballard: "Clostridium difficile toxins: mechanism of action and role in disease." in: Clinical microbiology reviews, Vol. 18, Issue 2, pp. 247-63, 2005 (PubMed).

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