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Aquaporin 4 antibody (C-Term) (Biotin)

AQP4 Reactivity: Rat WB, IHC, IF, ICC Host: Rabbit Polyclonal Biotin
Catalog No. ABIN2486394
  • Target See all Aquaporin 4 (AQP4) Antibodies
    Aquaporin 4 (AQP4)
    Binding Specificity
    • 20
    • 16
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 65
    • 58
    • 58
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    Rat
    Host
    • 73
    • 18
    • 1
    Rabbit
    Clonality
    • 72
    • 20
    Polyclonal
    Conjugate
    • 49
    • 10
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Aquaporin 4 antibody is conjugated to Biotin
    Application
    • 74
    • 46
    • 25
    • 25
    • 21
    • 15
    • 14
    • 14
    • 13
    • 13
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    Detects ~35 kDa. May detect larger glycosylated bands ~50 kDa.
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Protein A Purified
    Immunogen
    Produced against the C-terminal peptide (Sequence N-CTKGSYMEVEDNRSQVETED) of rat aquaporin 4
    Top Product
    Discover our top product AQP4 Primary Antibody
  • Application Notes
    • WB (1:2000)
    • IHC (1:200)
    • ICC/IF (1:400)
    • optimal dilutions for assays should be determined by the user.
    Comment

    0.5 μg/ml of ABIN2486394 was sufficient for detection of aquaporin 4 in 10 μg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Conjugated antibodies should be stored at 4°C
  • Target
    Aquaporin 4 (AQP4)
    Alternative Name
    Aquaporin 4 (AQP4 Products)
    Synonyms
    zgc:100922 antibody, si:ch211-192k9.1 antibody, AQP4 antibody, LOC100232616 antibody, HMIWC2 antibody, MIWC antibody, WCH4 antibody, AQP-4 antibody, AQP4.M23 antibody, MIWC2 antibody, Miwc antibody, aquaporin-4 antibody, aquaporin 4 antibody, aquaporin 4 L homeolog antibody, aqp4 antibody, AQP4 antibody, aqp4.L antibody, Aqp4 antibody
    Background
    Aquaporins selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. Known as water channels, they are integral membrane pore proteins (1, 2). Aquaporin 4 is constitutively expressed in the basolateral cell membrane of principal collecting duct cells in the kidney and provide a pathway for water to exit these cells (3). It is also expressed in astrocytes and is up regulated by direct insult to the CNS (4). Aquaporin 4 has been proposed as the primary autoimmune target in neuromyelitis optica ( 5, 6).
    Gene ID
    25293
    NCBI Accession
    NP_036957
    UniProt
    P47863
    Pathways
    Sensory Perception of Sound
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