CTDSP2 antibody (AA 25-150) (Biotin)

Catalog No. ABIN2559712

Product Details anti-CTDSP2 Antibody (Biotin)

Target: CTDSP2 (CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 2 (CTDSP2))

Binding Specificity: AA 25-150

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTDSP2 antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CTDSP2

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for CTDSP2

Target: CTDSP2 (CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 2 (CTDSP2))

Alternative Name: CTDSP2 (CTDSP2 Products)

Synonyms: fb16c04 antibody, wu:fb16c04 antibody, zgc:77714 antibody, MGC68415 antibody, CTDSP2 antibody, OS4 antibody, PSR2 antibody, SCP2 antibody, AI586070 antibody, D10Ertd73e antibody, OS-4 antibody, CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 antibody, CTD small phosphatase 2 L homeolog antibody, CTD small phosphatase 2 antibody, ctdsp2 antibody, ctdsp2.L antibody, CTDSP2 antibody, Ctdsp2 antibody

Background:

Synonyms: OS4, PSR2, SCP2, Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2, Nuclear LIM interactor-interacting factor 2, NLI-interacting factor 2, Protein OS-4, Small C-terminal domain phosphatase 2, Small CTD phosphatase 2, CTDSP2, NIF2

Background: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.

Gene ID: 10106

UniProt: O14595

Pathways: ER-Nucleus Signaling