TYRO3 antibody (pTyr681, pTyr749)

Catalog No. ABIN2568354

The Rabbit Polyclonal anti-TYRO3 antibody is suitable to detect TYRO3 in samples from Human, Mouse and Rat. It has been validated for WB and IHC.

Quick Overview for TYRO3 antibody (pTyr681, pTyr749) (ABIN2568354)

Target: TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TYRO3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-TYRO3 Antibody

Binding Specificity: pTyr681, pTyr749

Specificity: The antibody detects endogenous levels of MER/SKY only when phosphorylated at tyrosine 749/681.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: MER/SKY (phospho Tyr749/681) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 749/681 (K-I-Y (p)-S-G) derived from Human MER/SKY .

Isotype: IgG

Application Details

Application Notes: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store antibody at -20°C for up to one year.

Target Details for TYRO3

Target: TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))

Alternative Name: MER/SKY

Background: This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).

Molecular Weight: 97 kDa

Gene ID: 10461, 7301

NCBI Accession: NP_006334

UniProt: Q12866, Q06418

Pathways: RTK Signaling