Bcl-2 antibody

Catalog No. ABIN264903

The Sheep Polyclonal anti-Bcl-2 antibody (ABIN264903) specifically detects Bcl-2 in WB, IF and IP. The antibody is reactive with Human, Rat and Dog samples.

Quick Overview for Bcl-2 antibody (ABIN264903)

Target: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Reactivity: Human, Rat, Dog

Host: Sheep

Clonality: Polyclonal

Conjugate: This Bcl-2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Product Details anti-Bcl-2 Antibody

Specificity: This antibody reacts to bcl-2.

Purification: Purified

Isotype: IgG

Application Details

Application Notes: Western Blot: 1: 5,000. Immunoprecipitation. Immunofluorescence: 1: 5000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Target Details for Bcl-2

Target: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Alternative Name: Bcl-2

Background: Human hematopoetic malignancies are often characterized by gene rearrangements that deregulate gene expression. Antibodies to human bcl-2 (B cell leukemia/lymphoma 2) are directed against the gene isolated at the chromosomal breakpoint t(14,18) Bcl-2 which suppress programmed cell death (apoptosis) and appears to be modulated by association with bax, a cell death promoter.Synonyms: Apoptosis regulator Bcl-2, B-Cell CLL/lymphoma 2, BCL2, Bcl-2 alpha

Gene ID: 596

NCBI Accession: NP_000624

UniProt: P10415

Pathways: MAPK Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling