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Netrin 1 antibody

NTN1 Reactivity: Human, Mouse, Rat, Monkey, Cow, Cat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN265184
  • Target See all Netrin 1 (NTN1) Antibodies
    Netrin 1 (NTN1)
    Reactivity
    • 47
    • 43
    • 35
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Monkey, Cow, Cat
    Host
    • 56
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    Rabbit
    Clonality
    • 61
    • 9
    Polyclonal
    Conjugate
    • 39
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This Netrin 1 antibody is un-conjugated
    Application
    • 53
    • 22
    • 20
    • 13
    • 13
    • 7
    • 6
    • 5
    • 5
    • 4
    • 4
    • 2
    • 1
    Western Blotting (WB)
    Specificity
    This antibody detects NTN1. Tested on MDCKII cell lysates.
    Purification
    Purified
    Immunogen
    Synthetic peptide derived from the human Netrin 1 protein
    Isotype
    IgG
    Top Product
    Discover our top product NTN1 Primary Antibody
  • Application Notes
    Western blot (0.5-2 μg/mL).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    Phosphate buffered saline with 0.08 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
  • Target
    Netrin 1 (NTN1)
    Alternative Name
    Netrin-1 (NTN1 Products)
    Synonyms
    ntn1-A antibody, Netrin-1 antibody, NTN1 antibody, unc-6 antibody, MGC147073 antibody, NTN1L antibody, AI561871 antibody, BC019633 antibody, netrin-1 antibody, netrin 1 L homeolog antibody, netrin 1 antibody, ntn1.L antibody, NTN1 antibody, ntn1 antibody, Ntn1 antibody
    Background
    Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis. Netrin 1's main receptor is DCC (deleted in colorectal cancer- a putative tumor suppressor gene whose expression is lost in numerous cancers). DCC belongs to the so-called family of dependence receptors. These receptors induce apoptosis when their ligand is absent, thus conferring a state of cellular dependence on Netrin 1 availability. The DCC/netrin-1 duo regulates neuron survival during nervous system development. The mechanism(s) by which Netrin 1/ DCC triggers cell death are still unknown. The localization of DCC to lipid rafts appears to be a prerequisite for its proapoptotic activity.Synonyms: NTN1, NTN1L
    Gene ID
    9423
    NCBI Accession
    NP_004813
    UniProt
    O95631
    Pathways
    Regulation of Cell Size
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