CSAG2 antibody

Catalog No. ABIN265186

Product Details anti-CSAG2 Antibody

Target: CSAG2 (CSAG Family, Member 2 (CSAG2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CSAG2 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects Trag 3. Trag 3 is weakly expressed in kidney. Expressed in various tumor cell lines including carcinomas, myeloid and lymphoid malignancies, melanomas and prostate cancer. Overexpressed in taxol-resistant breast cancer line MDA 435(TR) and the doxorubicin-resistant multiple myelanoma lines 8226/Dox(40) and 8226/MDR(10).

Purification: Affinity chromatography

Immunogen: Synthetic peptide derived from the human Trag-3 protein

Isotype: IgG

Application Details

Application Notes: Western blot: 0.5-2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.

Target Details for CSAG2

Target: CSAG2 (CSAG Family, Member 2 (CSAG2))

Alternative Name: CSAG2 (CSAG2 Products)

Synonyms: CSAG1 antibody, CSAG3B antibody, CSAG3 antibody, CT24.2 antibody, TRAG-3 antibody, TRAG3 antibody, chondrosarcoma-associated gene 2/3 protein antibody, CSAG family member 2 antibody, LOC705860 antibody, LOC738247 antibody, CSAG2 antibody

Background: The expression of the cancer-testis antigen Taxol resistance-associated gene-3 (TRAG-3) is associated with acquired paclitaxel (Taxol) resistance, and is expressed in a variety of cancers - e.g., breast cancer, leukemia, and melanoma. Overexpressed in taxol-resistant breast cancer line MDA 435(TR) and the doxorubicin-resistant multiple myelanoma lines 8226/Dox(40) and 8226/MDR(10)V. Weakly expressed in kidney. TRAG-3 is an attractive target for immunotherapy of cancer. First identified as a novel cancer/testis antigen, TRAG-3, (Taxol Resistance Associated Gene-3) was initially discovered in a search for new genes involved in drug resistance. Early studies of TRAG-3 revealed a minimal to absent expression in normal tissues and a marked over-expression in many carcinoma cell lines including several melanoma lines. By RT-PCR evaluation of TRAG-3 two transcripts are seen in many carcinoma cell lines with products in the the 799 bp and a second alternatively spliced transcript.Synonyms: CT24.2, Cancer/testis antigen 24.2, Chondrosarcoma-associated gene 2/3 protein, TRAG-3, TRAG3, Taxol-resistant-associated gene 3 protein

Gene ID: 389903

NCBI Accession: NP_001074317

UniProt: Q9Y5P2