FLT3 antibody (APC)

Catalog No. ABIN2658480

The APC-conjugated Rat Monoclonal anti-FLT3 antibody (Clone A2F10) (ABIN2658480) specifically detects FLT3 in WB, FACS, ICC and BR. The antibody is reactive with Mouse samples.

Quick Overview for FLT3 antibody (APC) (ABIN2658480)

Target: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This FLT3 antibody is conjugated to APC

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunocytochemistry (ICC), Blocking Reagent (BR)

Clone: A2F10

Product Details anti-FLT3 Antibody (APC)

Purification: The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for FLT3

Target: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Alternative Name: CD135

Background: CD135, also known as Flk-2, Flt3, and Ly-72, is a type III tyrosine kinase receptor. It is expressed on early B lymphoid lineage cells in bone marrow, on primitive myeloid progenitors within the BM CD34+ cell population. Ligation of Flk-2 with Flt3 ligand regulates the growth of hematopoietic stem cells and promotes the survival of primitive hematopoietic progenitor cells with myeloid as well as B lymphoid potential. It was reported that the receptor tyrosine kinase Flt3 is required for dendritic cell development. Combined signaling through interleukin-7 receptors and Flt3 selectively promotes B-cell commitment and differentiation from uncommitted murine bone marrow progenitor cells.

Pathways: RTK Signaling