C-Type Lectin Domain Family 1, Member B (CLEC1B) antibody (PE)

Catalog No. ABIN2662694

The PE-conjugated Rat Monoclonal anti-C-Type Lectin Domain Family 1, Member B antibody (Clone 17D9-CLEC2) (ABIN2662694) specifically detects C-Type Lectin Domain Family 1, Member B in ICFC. The antibody is reactive with Mouse samples.

Quick Overview for C-Type Lectin Domain Family 1, Member B (CLEC1B) antibody (PE) (ABIN2662694)

Target: C-Type Lectin Domain Family 1, Member B (CLEC1B)

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: PE

Application: Intracellular Flow Cytometry (ICFC)

Clone: 17D9-CLEC2

Product Details

Purification: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Isotype: IgG2b kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details

Target: C-Type Lectin Domain Family 1, Member B (CLEC1B)

Alternative Name: CLEC2

Background: CLEC-2, also known as CLEC1B and CLEC1B1, is C-type lectin-like receptor with a single cytoplasmic YXXL sequence known as a hem-immunoreceptor tyrosine-based activation motif (hemITAM). CLEC-2 is highly expressed on resting platelets and megakaryocytes and at a lower levels on several hematopoietic cells including monocytes, macrophages, dendritic cells, and granulocytes. The first ligand that was identified for CLEC-2 was the snake venom toxin rhodocytin, podoplanin has also been identified as an endogenous ligand for CLEC-2. Exposure of platelets to rhodocytin leads tyrosine phosphorylation of the ITAM-like motif and Syk-dependent platelet activation. CLEC-2 also functions as an activation receptor on monoyctes and neutrophils to induce phagocytosis and proinflammatory cytokine production.