CD226 antibody (PE)

Catalog No. ABIN2663191

The Rat Monoclonal anti-CD226 antibody has been validated for WB, FACS, IHC, IP and ICC. It is suitable to detect CD226 in samples from Mouse.

Quick Overview for CD226 antibody (PE) (ABIN2663191)

Target: CD226

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This CD226 antibody is conjugated to PE

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Clone: 10E5

Product Details anti-CD226 Antibody (PE)

Purification: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Isotype: IgG2b, IgG2b kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for CD226

Target: CD226

Alternative Name: CD226

Background: CD226 (DNAM-1) is constitutively expressed on native CD8+ cells and on CD4+ T cells,macrophages and NK cells.This antibody (10E5) was reported to bind about 40 % of inactivated CD4+ cells and binds only to differentiated Th1 cells, but not to Th2 or Th0 cells.It is also reported to suppress antigen-specific T cell expansion and EAE(experimental allergic encephalitis) mediated by Th1 cells.

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints