SIGLEC7 antibody (PE)

Catalog No. ABIN2663372

The PE-conjugated Mouse Monoclonal anti-SIGLEC7 antibody (Clone 6-434) (ABIN2663372) specifically detects SIGLEC7 in FACS and ICFC. The antibody is reactive with Human samples.

Quick Overview for SIGLEC7 antibody (PE) (ABIN2663372)

Target: SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SIGLEC7 antibody is conjugated to PE

Application: Flow Cytometry (FACS), Intracellular Flow Cytometry (ICFC)

Clone: 6-434

Product Details anti-SIGLEC7 Antibody (PE)

Purification: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for SIGLEC7

Target: SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))

Alternative Name: CD328

Background: Siglec-7, also known as p75/AIRM1, is a 75 kD type I transmembrane protein and a member of the family of sialic acid-binding immunoglobulin-like lectins (Siglecs). It is primarily found on NK cells and monocytes. The cytoplasmic domain of Siglec-7 contains immunoreceptor tyrosine-based inhibitory motif (ITIM). CD328 mediates sialic acid-dependent cell-cell binding and functions as an inhibitory receptor of NK cells. CD328 preferentially binds to sialylated glycans with α2,8 disialyl and α2,6 sialyl residues.