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Caspase 1 antibody
CASP1
Reactivity: Mouse
FACS
Host: Rat
Monoclonal
5B10
unconjugated
Product Details anti-Caspase 1 Antibody
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Target
See all Caspase 1 (CASP1) Antibodies
Caspase 1 (CASP1)
Reactivity
All reactivities for Caspase 1 antibodies
Mouse
Host
All hosts for Caspase 1 antibodies
Rat
Clonality
All clonalities for Caspase 1 antibodies
Monoclonal
Conjugate
All conjugates for Caspase 1 antibodies
This Caspase 1 antibody is un-conjugated
Application
All applications for Caspase 1 antibodies
Flow Cytometry (FACS)
Purification
The antibody was purified by affinity chromatography.
Clone
5B10
Isotype
IgG2a
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Discover our top product CASP1 Primary Antibody
Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
The antibody solution should be stored undiluted between 2°C and 8°C.
Target Details for Caspase 1
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Target
Caspase 1 (CASP1)
Alternative Name
Caspase-1 (CASP1 Products )
Synonyms
ICE antibody, IL1BC antibody, P45 antibody, Il1bc antibody, Ice antibody, CASP1 antibody, CG5370 antibody, DCP-1 antibody, DCP1 antibody, Dcp1 antibody, Dmel\\CG5370 antibody, ccp1 antibody, dcp-1 antibody, dcp1 antibody, l(2)01862 antibody, l(2)02132 antibody, caspase 1 antibody, caspase 1, apoptosis-related cysteine peptidase antibody, caspase 4, apoptosis-related cysteine peptidase antibody, Death caspase-1 antibody, caspase-1 antibody, caspase antibody, caspase recruitment domain-containing protein 16 antibody, caspase 4 antibody, CASP1 antibody, Casp1 antibody, CASP4 antibody, Dcp-1 antibody, Caspase1 antibody, LOC5564196 antibody, LOC451519 antibody
Background
Caspase -1 plays a vital role in cleaving the inactive procytokine pro-IL-1 beta to generate the active 17 kd mature form of IL-1beta, a key mediator of inflammation. Active caspase-1 (ICE) is derived a single proenzyme of 45 Kd. An active ICE comprises two subunits of P20 and two subunits of P10 after removal a large amino-terminal pro-domain and a small linker peptide. Caspase-1 is reported to be involved in CD95- mediated apoptosis. Four alternatively spliced variants of caspase-1 have been reported, with mw ranging from 30-48 kd.
Pathways
Apoptosis , Interferon-gamma Pathway , Positive Regulation of Endopeptidase Activity , Inflammasome
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