IL-34 antibody

Catalog No. ABIN2665167

Product Details anti-IL-34 Antibody

Target: IL-34 (IL34) (Interleukin 34 (IL34))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This IL-34 antibody is un-conjugated

Application: Immunoprecipitation (IP)

Purification: The antibody was purified by affinity chromatography.

Clone: C051-77

Isotype: IgG2c

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for IL-34

Target: IL-34 (IL34) (Interleukin 34 (IL34))

Alternative Name: IL-34 (IL34 Products)

Synonyms: C16orf77 antibody, IL-34 antibody, 2010004A03Rik antibody, AI593503 antibody, C18H16ORF77 antibody, interleukin 34 antibody, IL34 antibody, Il34 antibody

Background: IL-34 is a glycoprotein that plays important roles in the proliferation, survival, and differentiation of monocytes and macrophages. IL-34 is expressed in the heart, brain, lung, liver, kidney, thymus, spleen, and other organs. It specifically binds to CD115/M-CSF receptor (CSF-1 receptor or c-Fms) and activates ERK1/2 phosphorylation. The function of IL-34 overlaps with CSF-1 to regulate myeloid lineage development. IL-34 also promotes inflammatory processes and regulates osteoclast proliferation, differentiation, and bone reabsorption.

Pathways: RTK Signaling