NCOR2 antibody (AA 2004-2310)

Catalog No. ABIN2668570

There is 1 publication for this product available. The Mouse Monoclonal anti-NCOR2 antibody is suitable to detect NCOR2 in samples from Human. It has been validated for WB.

Quick Overview for NCOR2 antibody (AA 2004-2310) (ABIN2668570)

Target: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NCOR2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 5-10

Product Details anti-NCOR2 Antibody

Binding Specificity: AA 2004-2310

Purpose: SMRT / NCoR2 antibody (mAb) (Clone 5.10)

Purification: Protein G Chromatography

Immunogen: This SMRT / NCoR2 antibody was raised against a recombinant protein corresponding to amino acids 2004-2310 of human SMRT / NCoR2.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1 μg/μL

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

References for anti-NCOR2 antibody (ABIN2668570)

Huang, Zhang, Miska, Guenther, Kouzarides, Lazar: "Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway." in: Genes & development, Vol. 14, Issue 1, pp. 45-54, (2000) (PubMed).

Target Details for NCOR2

Target: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Alternative Name: SMRT / NCoR2

Background: SMRT / NCoR2 (Nuclear receptor corepressor 2, CTG repeat protein 26, SMAP270, Silencing mediator of retinoic acid and thyroid hormone receptor, Thyroid and retinoic-acid-receptor-associated corepressor, TRAC) is a transcriptional corepressor for nuclear receptors. SMRT / NCoR2 has been shown to play a role in regulating immune response, mediating DNA repair, and in neuronal differentiation and cardiac development. SMRT / NCoR2 is part of a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. It also includes TBL1, TBLR1, and GPS2 that help stabilize the overall structure of the complex. SMRT / NCoR2 mediates the transcriptional repression activity of nuclear receptors by promoting histone deacetylation and chromatin condensation, thus preventing access of the basal transcription machinery.

Molecular Weight: 300 kDa

Gene ID: 9612

NCBI Accession: NP_006303

Pathways: Notch Signaling, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha