Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1) antibody

Details for Product No. ABIN2668587
Antigen
Reactivity
Mouse (Murine), Rat (Rattus)
146
78
53
17
7
7
5
4
4
3
1
Host
Mouse
138
14
10
3
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
13
12
12
9
9
9
2
2
2
2
2
2
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
122
112
50
15
13
3
2
1
1
1
Options
Immunogen This MASH1 antibody was raised against a full-length protein corresponding to rat MASH1.
Clone 24B7-2D11-1
Isotype IgG1
Purification Protein A Chromatography
Antigen
Alternative Name MASH1 (ASCL1 Antibody Abstract)
Background The MASH1 (achaete-scute complex homolog 1 (Drosophila), ASCL1, ASH1, HASH1) gene encodes a protein that is a basic helix-loop-helix transcription factor that may play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcriptional activation by binding to the E box motif.
Molecular Weight 34 kDa
Gene ID 64186
Pathways Dopaminergic Neurogenesis
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1 μg/μL
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice

Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Storage -20 °C
Storage Comment Antibodies in solution can be stored at -20 °C for 2 years.
Expiry Date 6 months
Product cited in: Ivaniutsin, Chen, Mason, Price, Pratt: "Adenomatous polyposis coli is required for early events in the normal growth and differentiation of the developing cerebral cortex." in: Neural development, Vol. 4, Issue 1, pp. 3, 2009 (PubMed).

Ralston, Chiriboga, Nonaka: "MASH1: a useful marker in differentiating pulmonary small cell carcinoma from Merkel cell carcinoma." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 21, Issue 11, pp. 1357-62, 2008 (PubMed).

Lo, Johnson, Wuenschell, Saito, Anderson: "Mammalian achaete-scute homolog 1 is transiently expressed by spatially restricted subsets of early neuroepithelial and neural crest cells." in: Genes & development, Vol. 5, Issue 9, pp. 1524-37, 1991 (PubMed).