ESR2 antibody (AA 212-477)

Catalog No. ABIN2668755

This Mouse Monoclonal antibody specifically detects ESR2 in WB, IHC and IP. It exhibits reactivity toward Human. It has been mentioned in 2+ publications

Quick Overview for ESR2 antibody (AA 212-477) (ABIN2668755)

Target: ESR2 (Estrogen Receptor 2 (ESR2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ESR2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Clone: CO1531

Product Details anti-ESR2 Antibody

Binding Specificity: AA 212-477

Purpose: Estrogen Receptor beta antibody (mAb) (Clone CO1531)

Purification: Protein G Chromatography

Immunogen: This Estrogen Receptor beta antibody was raised against a recombinant protein corresponding to amino acids 212-477 of human Estrogen Receptor beta.

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1 μg/μL

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

References for anti-ESR2 antibody (ABIN2668755)

Leong, Sloan, Nash, Greene: "Recruitment of histone deacetylase 4 to the N-terminal region of estrogen receptor alpha." in: Molecular endocrinology (Baltimore, Md.), Vol. 19, Issue 12, pp. 2930-42, (2005) (PubMed).

Dan, Cheung, Scriven, Moore: "Epitope-dependent localization of estrogen receptor-alpha, but not -beta, in en face arterial endothelium." in: American journal of physiology. Heart and circulatory physiology, Vol. 284, Issue 4, pp. H1295-306, (2003) (PubMed).

Target Details for ESR2

Target: ESR2 (Estrogen Receptor 2 (ESR2))

Alternative Name: Estrogen Receptor beta

Background: ERb (estrogen receptor b) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding and activation of transcription. ERb localizes to the nucleus where it may form a homodimer or a heterodimer with ER alpha. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer and osteoporosis.

Molecular Weight: 59 kDa

Gene ID: 2100

NCBI Accession: NP_001428

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling