Lamin A/C antibody (AA 430-545)

Catalog No. ABIN2668844

This anti-Lamin A/C antibody is a Mouse Monoclonal antibody detecting Lamin A/C in WB, IF and ICC. Suitable for Human, Mouse, Rat, Monkey and Hamster. This Primary Antibody has been cited in 3+ publications.

Quick Overview for Lamin A/C antibody (AA 430-545) (ABIN2668844)

Target: Lamin A/C (LMNA)

Reactivity: Human, Mouse, Rat, Monkey, Hamster

Host: Mouse

Clonality: Monoclonal

Conjugate: This Lamin A/C antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 3A6-4C11

Product Details anti-Lamin A/C Antibody

Binding Specificity: AA 430-545

Purification: Culture Supernatant

Immunogen: This Lamin A/C antibody was raised against a recombinant protein corresponding to amino acids 430-545 of human Lamin A.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1 μg/μL

Buffer: Cell culture supernatant containing mouse IgG, 30 % glycerol, 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice:

Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Storage: -20 °C

Storage Comment: Antibodies in solution can be stored at -20 °C for 2 years.

Expiry Date: 6 months

References for anti-Lamin A/C antibody (ABIN2668844)

Gesson, Rescheneder, Skoruppa, von Haeseler, Dechat, Foisner: "A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha." in: Genome research, Vol. 26, Issue 4, pp. 462-73, (2016) (PubMed).

Kim, Zheng: "Generation and characterization of a conditional deletion allele for Lmna in mice." in: Biochemical and biophysical research communications, Vol. 440, Issue 1, pp. 8-13, (2013) (PubMed).

Eckersley-Maslin, Bergmann, Lazar, Spector: "Lamin A/C is expressed in pluripotent mouse embryonic stem cells." in: Nucleus (Austin, Tex.), Vol. 4, Issue 1, pp. 53-60, (2013) (PubMed).

Target Details for Lamin A/C

Target: Lamin A/C (LMNA)

Alternative Name: Lamin A/C

Molecular Weight: 75 kDa

Gene ID: 4000

Pathways: Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus