Monoclonal antibody DX29 reacts with inducible costimulatory (ICOS) molecule. ICOS is a homodimeric membrane glycoprotein, member of the CD28 family, of approximately 50 - 60 kDa, highly expressed on activated T cells. It is the receptor for B7 related protein 1 (B7RP-1) and also, like CD28, ICOS is costimulatory signal for T cell activation, proliferation and cytokine production. It is not expressed on resting or activated B cells, monocytes, NK cells, granulocytes, dendritic cells or platelets. Unlike the constitutively expressed CD28, ICOS expression is de novo. Reports describe similarities of CD28 and ICOS in T cell activation, however, it has been suggested that ICOS may play an important role in IL-10 production. In presence IL-10, purified recombinant human ICOS significantly increased in vitro B cell growth stimulated by pokeweed mitogen (PWM) and enhanced production of IgG. Profile of ICOS (DX29) reactivity on PHA-stimulated peripheral blood mononuclear cells analyzed by flow cytometry. Second step staining with Cat. No. 555988.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
Store undiluted at 4°C.
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