CD40 antibody
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- Target See all CD40 Antibodies
- CD40
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This CD40 antibody is un-conjugated
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Application
- Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Brand
- BD Pharmingen™
- Characteristics
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This antibody reacts with a 45-48 kDa type I integral membrane glycoprotein present on peripheral blood and tonsillar B cells, but not expressed on terminally differentiated B cells. CD40 is also present on some epithelial cells, carcinomas and lymphoid dendritic cells. This antibody is useful for studies of B-cell growth and function. Anti-CD40 antibodies have been reported to stimulated B-cell proliferation when costimulated with anti-μ, anti-CD20 antibodies or with phorbol esters. 5C3 is capable of inducing B-cell proliferation when presented with IL-4. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of peripheral blood lymphocytes analyzed on a FACScan
BD Pharmingen™ Purified Mouse Anti-Human CD40 - Purified - Clone 5C3 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Clone
- 5C3
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product CD40 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store undiluted at 4°C.
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CD40 is functionally expressed on human thymic epithelial cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 3, pp. 775-82, (1992) (PubMed).
: "The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis." in: Cell, Vol. 66, Issue 2, pp. 233-43, (1991) (PubMed).
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CD40 is functionally expressed on human thymic epithelial cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 3, pp. 775-82, (1992) (PubMed).
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- Target
- CD40
- Alternative Name
- CD40 (CD40 Products)
- Synonyms
- Bp50 antibody, CDW40 antibody, TNFRSF5 antibody, p50 antibody, AI326936 antibody, GP39 antibody, HIGM1 antibody, IGM antibody, IMD3 antibody, T-BAM antibody, TRAP antibody, Tnfrsf5 antibody, TNFSF5 antibody, CD40 molecule antibody, CD40 antigen antibody, CD40 antibody, Cd40 antibody
- Pathways
- NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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