CD51/CD61 antibody

Catalog No. ABIN2689327

Product Details anti-CD51/CD61 Antibody

Target: CD51/CD61 (ITGAV/ITGB3) (Integrin AlphaV, Integrin Beta3 (ITGAV/ITGB3))

Reactivity: Human, Rabbit

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD51/CD61 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Brand: BD Pharmingen™

Characteristics: Reacts with the integrin αvβ3 heterodimeric complex (CD51/CD61), which is expressed in high amounts on osteoclasts, endothelial cells, melanoma cells, and in very low amounts on platelets. This antibody has been reported to cross-react with chicken and rabbit, but not with rat, αvβ3. The integrin αvβ3, often referred to as the vitronectin receptor, binds several ligands in addition to vitronectin, and its binding to some ligands has been reported to be inhibited by the 23C6 mAb. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of M21 (melanoma) cells analyzed by flow cytometry

BD Pharmingen™ Purified Mouse Anti-Human CD51/CD61 - Purified - Clone 23C6 - Isotype Mouse IgG1, κ - Reactivity Hu, Rab - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: 23C6

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-CD51/CD61 antibody (ABIN2689327)

Nesbitt, Nesbit, Helfrich, Horton: "Biochemical characterization of human osteoclast integrins. Osteoclasts express alpha v beta 3, alpha 2 beta 1, and alpha v beta 1 integrins." in: The Journal of biological chemistry, Vol. 268, Issue 22, pp. 16737-45, (1993) (PubMed).

Target Details for CD51/CD61

Target: CD51/CD61 (ITGAV/ITGB3) (Integrin AlphaV, Integrin Beta3 (ITGAV/ITGB3))

Alternative Name: CD51/CD61 (ITGAV/ITGB3 Products)

Synonyms: CD51 antibody, MSK8 antibody, VNRA antibody, VTNR antibody, integrin subunit alpha V antibody, ITGAV antibody