GAS41 antibody

Catalog No. ABIN272151

Product Details anti-GAS41 Antibody

Target: GAS41 (YEATS Domain Containing 4)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GAS41 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects endogenous levels of GAS41 protein. (region surrounding Arg32)

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Purity: > 95 % pure by SDS-PAGE

Application Details

Application Notes: ELISA: 1: 5000approx. 1: 10000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: DO NOT FREEZE!

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for GAS41

Target: GAS41 (YEATS Domain Containing 4)

Alternative Name: YEATS4 (GAS41 Products)

Synonyms: 4930573H17Rik antibody, B230215M10Rik antibody, GAS41 antibody, NUBI-1 antibody, YAF9 antibody, YEATS4 antibody, NuBI-1 antibody, RGD1305741 antibody, zgc:100841 antibody, MGC89432 antibody, CG9207 antibody, Dmel\\CG9207 antibody, dGas41 antibody, GB13136 antibody, GLIOMAS 41 antibody, K2N11.8 antibody, K2N11_8 antibody, TAF14B antibody, TBP-ASSOCIATED FACTOR 14B antibody, NV13456 antibody, YEATS domain containing 4 antibody, YEATS domain containing 4 S homeolog antibody, CG9207 gene product from transcript CG9207-RA antibody, YEATS domain-containing protein 4 antibody, YEATS family protein antibody, Gas41 antibody, gas41 homologue, putative antibody, putative gas41 antibody, YEATS4 antibody, Yeats4 antibody, yeats4.S antibody, yeats4 antibody, Gas41 antibody, LOC412705 antibody, GAS41 antibody, Chro.20029 antibody, PB300718.00.0 antibody, PCHAS_122420 antibody, Smp_070760 antibody, LOC100121822 antibody

Background: Gene amplification is associated with tumor stage and progression in human gliomas. Several amplified loci are identified and comprise multiple genes. The glioma amplified sequence 41 (GAS41) is an evolutionarily conserved eukaryotic protein found in diverse species. GAS41 is related to the AF-9 and ENL proteins, which are putative transcription factors in some acute leukemias,and interacts with a component of the nuclear matrix, NuMA, in interphase cells. GAS41 has a dotted staining pattern in interphase nuclei and a uniform distribution in mitotic cells. GAS41 is ubiquitously expressed, with the highest levels of expression in human brain. In neuroblastoma, GAS41 is located in the nucleoli, but not in the nucleoplasm. GAS41 also binds to the MLL fusion partner AF-10, which is involved in two distinct chromosomal translocations associated with hematologic malignancy. In addition, GAS41 interacts with INI1 (integrase interactor 1), which is a human homolog of the yeast Snf5 protein, a component of the SWI/SNF complex. The GAS41 gene maps to human chromosome 12q13-q15.Synonyms: GAS41, Glioma-amplified sequence 41, NuBI-1, NuBI1, NuMA-binding protein 1, YEATS domain-containing protein 4

Molecular Weight: approx. 42 kDa

Gene ID: 8089

NCBI Accession: NP_006521

UniProt: O95619