RED1 antibody

Catalog No. ABIN272206

Product Details anti-RED1 Antibody

Target: RED1 (ADARB1) (Adenosine Deaminase, RNA-Specific, B1 (ADARB1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RED1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects endogenous levels of ADAR2 protein.

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.2, 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for RED1

Target: RED1 (ADARB1) (Adenosine Deaminase, RNA-Specific, B1 (ADARB1))

Alternative Name: ADARB1 / ADAR2 (ADARB1 Products)

Synonyms: ADARB1 antibody, RED1 antibody, ADAR2 antibody, DRABA2 antibody, DRADA2 antibody, 1700057H01Rik antibody, AW124433 antibody, AW558573 antibody, Adar2 antibody, BB220382 antibody, D10Bwg0447e antibody, Red1 antibody, adar2 antibody, adarb1 antibody, red1 antibody, adenosine deaminase, RNA specific B1 antibody, adenosine deaminase, RNA-specific, B1 antibody, adenosine deaminase, RNA-specific, B1 L homeolog antibody, adenosine deaminase, RNA-specific, B1a antibody, ADARB1 antibody, adarb1 antibody, adarb1.L antibody, Adarb1 antibody, adarb1a antibody

Background: ADAR2, also designated adenosine deaminase, RNA-specific (RED1), RNA-editing enzyme 1, DRABA2, DRADA2, ADAR2α-L1, ADAR2α-L2 and ADAR2α-L3, mediates RNA editing by destabilizing RNA through deamination of adenosine to inosine. ADAR2 is responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. It can modify its own pre-mRNA and generate new splice sites. Translocation of endogenous ADAR2 from the nucleolus to the nucleoplasm results in increased editing of endogenous ADAR2 substrates. Alternative splicing of this gene results in several transcript variants that may influence RNA editing. RNA editing involves the deamination of adenosines at specific sites, the result of which can be a change in the amino acid sequence of the protein so that it differs from that predicted by the sequence of the DNA.Synonyms: DRADA2, Double-stranded RNA-specific editase 1, RED1, RNA-editing deaminase 1, RNA-editing enzyme 1, dsRNA adenosine deaminase

Molecular Weight: approx. 82 kDa

Gene ID: 104

NCBI Accession: NP_001103

UniProt: P78563