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GPX8 antibody (AA 38-209)

GPX8 Reactivity: Hepatitis C Virus (HCV) WB, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2745532
  • Target See all GPX8 Antibodies
    GPX8 (Glutathione Peroxidase 8 (GPX8))
    Binding Specificity
    • 8
    • 8
    • 7
    • 5
    • 2
    • 2
    AA 38-209
    Reactivity
    • 26
    • 1
    • 1
    Hepatitis C Virus (HCV)
    Host
    • 24
    • 2
    Rabbit
    Clonality
    • 26
    Polyclonal
    Conjugate
    • 12
    • 4
    • 3
    • 3
    • 2
    • 2
    This GPX8 antibody is un-conjugated
    Application
    • 21
    • 17
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunocytochemistry (ICC)
    Specificity
    Recognizes human GPx8.
    Cross-Reactivity
    Hepatitis C Virus (HCV)
    Immunogen
    Recombinant GPx8 (human) (aa 38-209) fused to a GST-tag.
    Top Product
    Discover our top product GPX8 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    In PBS containing 10 % glycerol and 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.
    Expiry Date
    12 months
  • Target
    GPX8 (Glutathione Peroxidase 8 (GPX8))
    Alternative Name
    GPx8 (GPX8 Products)
    Synonyms
    RGD1307506 antibody, zgc:56280 antibody, EPLA847 antibody, GPx-8 antibody, GSHPx-8 antibody, UNQ847 antibody, 2310016C16Rik antibody, AU017063 antibody, ATGPX8 antibody, F2K11.16 antibody, F2K11_16 antibody, glutathione peroxidase 8 antibody, glutathione peroxidase 8 antibody, glutathione peroxidase 8 (putative) antibody, Gpx8 antibody, gpx8 antibody, GPX8 antibody
    Target Type
    Viral Protein
    Background
    GPxs are glutathione peroxidases involved in balancing the H2O2 homeostasis in signaling cascades. GPxs have been known to catalyze the reduction of H2O2 or organic hydroperoxides to water or the corresponding alcohols, respectively, typically using glutathione (GSH) as reductant. GPx8 (probable glutathione peroxidase 8) is a 209-aa, 24 kDa protein with an N-terminal cytosolic tip, a predicted transmembrane segment and a catalytic domain located in the endoplasmic reticulum (ER) lumen. GPx8 is a CysGPxs with low glutathione peroxidase activity. A recent study identified GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease. GPx8 cleavage by NS3-4A occurs at Cys11, removing the cytosolic tip of GPx8 and was observed in different experimental systems as well as in liver biopsies from patients with chronic hepatitis C.
    UniProt
    Q8TED1
    Pathways
    Thyroid Hormone Synthesis
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