MERTK antibody (phosphorylated)

Catalog No. ABIN2746864

Product Details anti-MERTK Antibody

Target: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Binding Specificity: phosphorylated

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MERTK antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS), Confocal Microscopy (CM)

Purification: Affinity Purified

Immunogen: Phosphorylated synthetic peptide corresponding to unique amino acid sequence on MerTK protein.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.63 μg/μL

References for anti-MERTK antibody (ABIN2746864)

Das, Ghatak, Sinha, Chaffee, Ahmed, Parinandi, Wohleb, Sheridan, Sen, Roy: "Correction of MFG-E8 Resolves Inflammation and Promotes Cutaneous Wound Healing in Diabetes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 196, Issue 12, pp. 5089-100, (2017) (PubMed).

Zhang, Fang, Wu, Ding, Xu, Liu: "Mer receptor tyrosine kinase negatively regulates lipoteichoic acid-induced inflammatory response via PI3K/Akt and SOCS3." in: Molecular immunology, Vol. 76, pp. 98-107, (2017) (PubMed).

Cai, Thorp, Doran, Subramanian, Sansbury, Lin, Spite, Fredman, Tabas: "MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Issue 23, pp. 6526-31, (2016) (PubMed).

Nguyen, Tsou, Calarese, Kimani, Singh, Hsieh, Liu, Lu, Wu, Garforth, Almo, Kotenko, Birge: "Overexpression of MERTK receptor tyrosine kinase in epithelial cancer cells drives efferocytosis in a gain-of-function capacity." in: The Journal of biological chemistry, Vol. 289, Issue 37, pp. 25737-49, (2015) (PubMed).

Ginisty, Gély-Pernot, Abaamrane, Morel, Arnault, Coronas, Benzakour: "Evidence for a subventricular zone neural stem cell phagocytic activity stimulated by the vitamin K-dependent factor protein S." in: Stem cells (Dayton, Ohio), Vol. 33, Issue 2, pp. 515-25, (2015) (PubMed).

Law, Parinot, Chatagnon, Gravez, Sahel, Bhattacharya, Nandrot: "Cleavage of Mer tyrosine kinase (MerTK) from the cell surface contributes to the regulation of retinal phagocytosis." in: The Journal of biological chemistry, Vol. 290, Issue 8, pp. 4941-52, (2015) (PubMed).

Wang, Moncayo, Morin, Xue, Grzmil, Lino, Clément-Schatlo, Frank, Merlo, Hemmings: "Mer receptor tyrosine kinase promotes invasion and survival in glioblastoma multiforme." in: Oncogene, Vol. 32, Issue 7, pp. 872-82, (2013) (PubMed).

Fraineau, Monvoisin, Clarhaut, Talbot, Simonneau, Kanthou, Kanse, Philippe, Benzakour: "The vitamin K-dependent anticoagulant factor, protein S, inhibits multiple VEGF-A-induced angiogenesis events in a Mer- and SHP2-dependent manner." in: Blood, Vol. 120, Issue 25, pp. 5073-83, (2013) (PubMed).

Choi, Park, Lee, Byun, Youn, Choi, Woo, Kang: "Upregulation of Mer receptor tyrosine kinase signaling attenuated lipopolysaccharide-induced lung inflammation." in: The Journal of pharmacology and experimental therapeutics, Vol. 344, Issue 2, pp. 447-58, (2013) (PubMed).

Qin, Rodrigues: "Roles of αvβ5, FAK and MerTK in oxidative stress inhibition of RPE cell phagocytosis." in: Experimental eye research, Vol. 94, Issue 1, pp. 63-70, (2012) (PubMed).

Lee, Han, Byun, Park, Park, Chong, Cho, Kang: "Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-κB activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury." in: Journal of leukocyte biology, Vol. 91, Issue 6, pp. 921-32, (2012) (PubMed).

Lee, Lee, Youn, Choi, Song, Cho, Kang: "Preventing cleavage of Mer promotes efferocytosis and suppresses acute lung injury in bleomycin treated mice." in: Toxicology and applied pharmacology, Vol. 263, Issue 1, pp. 61-72, (2012) (PubMed).

Uehara, Shacter: "Auto-oxidation and oligomerization of protein S on the apoptotic cell surface is required for Mer tyrosine kinase-mediated phagocytosis of apoptotic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 4, pp. 2522-30, (2008) (PubMed).

Prasad, Rothlin, Burrola, Burstyn-Cohen, Lu, Garcia de Frutos, Lemke: "TAM receptor function in the retinal pigment epithelium." in: Molecular and cellular neurosciences, Vol. 33, Issue 1, pp. 96-108, (2007) (PubMed).

Sather, Kenyon, Lefkowitz, Liang, Varnum, Henson, Graham: "A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation." in: Blood, Vol. 109, Issue 3, pp. 1026-33, (2007) (PubMed).

Keating, Salzberg, Sather, Liang, Nickoloff, Anwar, Deryckere, Hill, Joung, Sawczyn, Park, Curran-Everett, McGavran, Meltesen, Gore, Johnson, Graham: "Lymphoblastic leukemia/lymphoma in mice overexpressing the Mer (MerTK) receptor tyrosine kinase." in: Oncogene, Vol. 25, Issue 45, pp. 6092-100, (2006) (PubMed).

Target Details for MERTK

Target: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Alternative Name: MERTK (MERTK Products)

UniProt: P57097

Pathways: RTK Signaling