PDE3A antibody

Catalog No. ABIN2747088

There are 18+ publications for this product available. The Rabbit Polyclonal anti-PDE3A antibody is suitable to detect PDE3A in samples from Human, Rat, Mouse, Monkey and Xenopus laevis. It has been validated for WB, IP, ELISA and IHC.

Quick Overview for PDE3A antibody (ABIN2747088)

Target: PDE3A (phosphodiesterase 3A, cGMP-Inhibited (PDE3A))

Reactivity: Human, Rat, Mouse, Monkey, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE3A antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), ELISA, Immunohistochemistry (IHC)

Product Details anti-PDE3A Antibody

Purification: Affinity Purified

Immunogen: Synthetic peptide selective only for PDE3A variants

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.72 μg/μL

References for anti-PDE3A antibody (ABIN2747088)

Fields, Koschinski, Zaccolo: "Sustained exposure to catecholamines affects cAMP/PKA compartmentalised signalling in adult rat ventricular myocytes." in: Cellular signalling, Vol. 28, Issue 7, pp. 725-32, (2017) (PubMed).

Yang, Kirton, MacDougall, Boyle, Deuchars, Frater, Ponnambalam, Hardy, White, Calaghan, Peers, Steele: "The Golgi apparatus is a functionally distinct Ca2+ store regulated by the PKA and Epac branches of the β1-adrenergic signaling pathway." in: Science signaling, Vol. 8, Issue 398, pp. ra101, (2016) (PubMed).

Rajagopal, Nalli, Kumar, Bhattacharya, Hu, Mahavadi, Grider, Murthy: "Cytokine-induced S-nitrosylation of soluble guanylyl cyclase and expression of phosphodiesterase 1A contribute to dysfunction of longitudinal smooth muscle relaxation." in: The Journal of pharmacology and experimental therapeutics, Vol. 352, Issue 3, pp. 509-18, (2015) (PubMed).

Petersen, Kristensen, Jeppesen, Grøndahl, Wissing, Macklon, Andersen: "Distribution and function of 3',5'-Cyclic-AMP phosphodiesterases in the human ovary." in: Molecular and cellular endocrinology, Vol. 403, pp. 10-20, (2015) (PubMed).

Mahavadi, Nalli, Kumar, Hu, Kuemmerle, Grider, Murthy: "Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle." in: American journal of physiology. Cell physiology, Vol. 307, Issue 4, pp. C402-11, (2014) (PubMed).

Vang, Housley, Dong, Basole, Ben-Sasson, Kream, Epstein, Clark, Brocke: "Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac." in: The Biochemical journal, Vol. 456, Issue 3, pp. 463-73, (2013) (PubMed).

Ückert, Waldkirch, Sonnenberg, Sandner, Kuczyk, Hedlund: "Expression and distribution of phosphodiesterase isoenzymes in the human seminal vesicles." in: The journal of sexual medicine, Vol. 8, Issue 11, pp. 3058-65, (2012) (PubMed).

Nishioka, Nishida, Ariyoshi, Jian, Saiki, Hirano, Nakaya, Sato, Kita, Iwamoto, Hirano, Inoue, Kurose: "Cilostazol suppresses angiotensin II-induced vasoconstriction via protein kinase A-mediated phosphorylation of the transient receptor potential canonical 6 channel." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 31, Issue 10, pp. 2278-86, (2011) (PubMed).

Dov, Abramovitch, Warwar, Nesher: "Diminished phosphodiesterase-8B potentiates biphasic insulin response to glucose." in: Endocrinology, Vol. 149, Issue 2, pp. 741-8, (2008) (PubMed).

Dony, Lai, Dumitrascu, Pullamsetti, Savai, Ghofrani, Weissmann, Schudt, Flockerzi, Seeger, Grimminger, Schermuly: "Partial reversal of experimental pulmonary hypertension by phosphodiesterase-3/4 inhibition." in: The European respiratory journal, Vol. 31, Issue 3, pp. 599-610, (2008) (PubMed).

Uckert, Oelke, Stief, Andersson, Jonas, Hedlund: "Immunohistochemical distribution of cAMP- and cGMP-phosphodiesterase (PDE) isoenzymes in the human prostate." in: European urology, Vol. 49, Issue 4, pp. 740-5, (2007) (PubMed).

Albrecht, Uckert, Oelke, Andersson, Jonas, Tröger, Hedlund: "Immunohistochemical distribution of cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human vagina: a potential forensic value?" in: Journal of forensic and legal medicine, Vol. 14, Issue 5, pp. 270-4, (2007) (PubMed).

Ückert, Oelke, Albrecht, Stief, Jonas, Hedlund: "Immunohistochemical description of cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human labia minora." in: The journal of sexual medicine, Vol. 4, Issue 3, pp. 602-608, (2007) (PubMed).

Oelke, Hedlund, Albrecht, Ellinghaus, Stief, Jonas, Andersson, Uckert: "Expression of cAMP and cGMP-phosphodiesterase isoenzymes 3, 4, and 5 in the human clitoris: immunohistochemical and molecular biology study." in: Urology, Vol. 67, Issue 5, pp. 1111-6, (2006) (PubMed).

Uckert, Hedlund, Waldkirch, Sohn, Jonas, Andersson, Stief: "Interactions between cGMP- and cAMP-pathways are involved in the regulation of penile smooth muscle tone." in: World journal of urology, Vol. 22, Issue 4, pp. 261-6, (2005) (PubMed).

Netherton, Maurice: "Vascular endothelial cell cyclic nucleotide phosphodiesterases and regulated cell migration: implications in angiogenesis." in: Molecular pharmacology, Vol. 67, Issue 1, pp. 263-72, (2005) (PubMed).

Uckert, Oelke, Waldkirch, Stief, Albrecht, Tröger, Jonas, Andersson, Hedlund: "Cyclic adenosine monophosphate and cyclic guanosine monophosphate-phosphodiesterase isoenzymes in human vagina: relation to nitric oxide synthase isoforms and vasoactive intestinal polypeptide-containing nerves." in: Urology, Vol. 65, Issue 3, pp. 604-10, (2005) (PubMed).

Mongillo, McSorley, Evellin, Sood, Lissandron, Terrin, Huston, Hannawacker, Lohse, Pozzan, Houslay, Zaccolo: "Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases." in: Circulation research, Vol. 95, Issue 1, pp. 67-75, (2004) (PubMed).

Target Details for PDE3A

Target: PDE3A (phosphodiesterase 3A, cGMP-Inhibited (PDE3A))

Alternative Name: PDE3A

NCBI Accession: NP_000912

UniProt: Q14432

Pathways: cAMP Metabolic Process