PDE3A antibody (AA 250-330)

Catalog No. ABIN7230556

The Rabbit Polyclonal anti-PDE3A antibody is suitable to detect PDE3A in samples from Human, Rat and Mouse. It has been validated for WB and ELISA.

Quick Overview for PDE3A antibody (AA 250-330) (ABIN7230556)

Target: PDE3A (phosphodiesterase 3A, cGMP-Inhibited (PDE3A))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE3A antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PDE3A Antibody

Binding Specificity: AA 250-330

Purpose: Rabbit Anti-PDE3A Polyclonal Antibody

Specificity: The antibody detects endogenous levels of PDE3A protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human PDE3A protein at AA range: 250-330

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PDE3A

Target: PDE3A (phosphodiesterase 3A, cGMP-Inhibited (PDE3A))

Alternative Name: PDE3A

Background: CGMP-inhibited 3',5'-cyclic phosphodiesterase A, Cyclic GMP-inhibited phosphodiesterase A, CGI-PDE APDE3A encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for PDE3A.

Molecular Weight: 125kD

Gene ID: 5139

UniProt: Q14432

Pathways: cAMP Metabolic Process