PHLPP2 antibody

Catalog No. ABIN2764064

The Rabbit Polyclonal anti-PHLPP2 antibody has been validated for WB, ELISA and IHC. It is suitable to detect PHLPP2 in samples from Human.

Quick Overview for PHLPP2 antibody (ABIN2764064)

Target: PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHLPP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-PHLPP2 Antibody

Cross-Reactivity: Human

Characteristics: PHLPP2, PH domain leucine-rich repeat-containing protein phosphatase 2, PH domain leucine-rich repeat-containing protein phosphatase-like, PHLPP-like,PHLPP2 is a protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.

Purification: Antigen Immunoaffinity Purification

Immunogen: Synthetic peptide derived from the human PHLPP2 protein

Isotype: Ig Fraction

Application Details

Application Notes: This antibody can be used for immunohistochemistry on formalin/paraffin sections (10-15 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for PHLPP2

Target: PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))

Alternative Name: PH domain leucine-rich repeat-containing protein phosphatase 2

UniProt: Q6ZVD8

Pathways: PI3K-Akt Signaling, Fc-epsilon Receptor Signaling Pathway