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Hexokinase 2 antibody (HK2) (N-Term) Primary Antibody

HK2 Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio) IHC, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2774067
$389.00
Plus shipping costs $45.00
100 μL
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  • Target
    Hexokinase 2 (HK2)
    Binding Specificity
    • 18
    • 11
    • 10
    • 8
    • 8
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 92
    • 35
    • 28
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)
    Host
    • 81
    • 22
    Rabbit
    Clonality
    • 82
    • 20
    Polyclonal
    Conjugate
    • 60
    • 9
    • 8
    • 5
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Hexokinase 2 antibody is un-conjugated
    Application
    • 89
    • 54
    • 50
    • 11
    • 9
    • 8
    • 6
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB)
    Sequence
    GTEHGEFLAL DLGGTNFRVL WVKVTDNGLQ KVEMENQIYA IPEDIMRGSG
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
    Characteristics
    This is a rabbit polyclonal antibody against HK2. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human HK2
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 917 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    Hexokinase 2 (HK2)
    Alternative Name
    HK2 (HK2 Antibody Abstract)
    Synonyms
    HKII, HXK2, AI642394, hexokinase-2, fi09d05, fi17h06, wu:fi09d05, wu:fi17h06, wu:fi31b04, zgc:55926, HK2, ARABIDOPSIS THALIANA HEXOKINASE 2, ATHXK2, F6F22.11, F6F22_11, HEXOKINASE 2, hexokinase 2, StHK2, hexokinase 2, hexokinase-2, hexokinase 2 L homeolog, HK2, Hk2, hk2, HXK2, LOC100032849, hk2.L, hxk2, LOC102577690
    Background
    Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. HK2 (hexokinase 2) is the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this protein is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-348 AI278414.1 4-351 349-732 CB160837.1 11-394 c 733-1006 BM912287.1 1-274 c 1007-1333 AI085541.1 1-327 c 1334-1477 AW134604.1 8-151 1478-4058 AF148513.1 1-2581 4059-5498 BC064369.1 2575-4014 5499-5615 BM706373.1 303-419 5616-7109 BC064369.1 4130-5623
    Alias Symbols: DKFZp686M1669, HKII, HXK2
    Protein Interaction Partner: UBQLN1, MAGEA12, SUMO2, SUMO3, UBC, EGFR, rev, H2AFV, WDR61, ARIH2, PDLIM1, PYGL, NUBP1, IPO5, HEXB, FNTA, FBXO6, PARK2, UBD, ITGA4, NUDCD3, UBQLN4, SLC2A4, ELAVL1, PTGDS, ZBTB17, PRKCE, IGFBP4,
    Protein Size: 917
    Molecular Weight
    102 kDa
    Gene ID
    3099
    NCBI Accession
    NM_000189, NP_000180
    UniProt
    P52789
    Pathways
    PI3K-Akt Signaling, Carbohydrate Homeostasis
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