CHMP2B antibody (N-Term)

Catalog No. ABIN2774093

Product Details anti-CHMP2B Antibody

Target: CHMP2B (Charged Multivesicular Body Protein 2B (CHMP2B))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHMP2B antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ASLFKKKTVD DVIKEQNREL RGTQRAIIRD RAALEKQEKQ LELEIKKMAK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against Chmp2b. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Rat Chmp2b

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 213 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CHMP2B

Target: CHMP2B (Charged Multivesicular Body Protein 2B (CHMP2B))

Alternative Name: Chmp2b (CHMP2B Products)

Synonyms: ALS17 antibody, CHMP2.5 antibody, DMT1 antibody, VPS2-2 antibody, VPS2B antibody, 1190006E07Rik antibody, RGD1306781 antibody, chmp2b antibody, chmp2bl antibody, zgc:77025 antibody, si:ch211-224m9.5 antibody, CHMP2B antibody, cg4618 antibody, chmp2.5 antibody, dmt1 antibody, vps2-2 antibody, vps2b antibody, CHMP2b-B antibody, chmp2b-a antibody, chmp2b-b antibody, charged multivesicular body protein 2B antibody, charged multivesicular body protein 2Bb antibody, charged multivesicular body protein 2Ba antibody, charged multivesicular body protein 2B pseudogene antibody, charged multivesicular body protein 2B S homeolog antibody, charged multivesicular body protein 2B L homeolog antibody, CHMP2B antibody, Chmp2b antibody, chmp2bb antibody, chmp2ba antibody, LOC747711 antibody, chmp2b.S antibody, chmp2b.L antibody

Background: Chmp2b is involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Chmp2b recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Chmp2b redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery Chmp2b also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Involved in cytokinesis .
Alias Symbols: RGD1306781
Protein Size: 213

Molecular Weight: 23 kDa

Gene ID: 363720

NCBI Accession: XM_001063932, XP_001063932