FDPS antibody (C-Term)

Catalog No. ABIN2774296

The Rabbit Polyclonal anti-FDPS antibody (ABIN2774296) specifically detects FDPS in WB and IHC. The antibody is reactive with Human, Rat, Mouse, Dog, Horse, Pig, Rabbit, Cow and Guinea Pig samples.

Quick Overview for FDPS antibody (C-Term) (ABIN2774296)

Target: FDPS (Farnesyl Diphosphate Synthase (FDPS))

Reactivity: Human, Rat, Mouse, Dog, Horse, Pig, Rabbit, Cow, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FDPS antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-FDPS Antibody

Binding Specificity: C-Term

Purpose: FDPS Antibody - C-terminal region

Sequence: VKYKTAFYSF YLPIAAAMYM AGIDGEKEHA NAKKILLEMG EFFQIQDDYL

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against FDPS. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP60781-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for FDPS

Target: FDPS (Farnesyl Diphosphate Synthase (FDPS))

Alternative Name: FDPS

Background:

Background Information: This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: Farnesyl diphosphate synthase

Alternative Symbols: FPS, FPPS, POROK9

Protein Name: Farnesyl pyrophosphate synthase

Molecular Weight: 38kDa

Gene ID: 2224

NCBI Accession: NP_001129294

UniProt: P14324

Pathways: Regulation of Muscle Cell Differentiation