PPP1R12A antibody (C-Term)
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- Target See all PPP1R12A Antibodies
- PPP1R12A (Myosin Phosphatase, Target Subunit 1 (PPP1R12A))
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Binding Specificity
- C-Term
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Reactivity
- Human, Mouse, Rat, Rabbit, Cow, Dog, Horse, Guinea Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PPP1R12A antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- QDSDENEQEQ QSDTEEGSNK KETQTDSISR YETSSTSAGD RYDSLLGRSG
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against PPP1R12A. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human PPP1R12A
- Top Product
- Discover our top product PPP1R12A Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 1030 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- PPP1R12A (Myosin Phosphatase, Target Subunit 1 (PPP1R12A))
- Alternative Name
- PPP1R12A (PPP1R12A Products)
- Synonyms
- 1200015F06Rik antibody, 5730577I22Rik antibody, AA792106 antibody, AV099298 antibody, D10Ertd625e antibody, Mypt1 antibody, M130 antibody, MBS antibody, MYPT1 antibody, M110 antibody, MBSP antibody, protein phosphatase 1, regulatory (inhibitor) subunit 12A antibody, protein phosphatase 1 regulatory subunit 12A antibody, protein phosphatase 1, regulatory subunit 12A antibody, Ppp1r12a antibody, PPP1R12A antibody
- Background
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Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase.
Alias Symbols: MBS, MGC133042, MYPT1, M130
Protein Interaction Partner: TP53, UBC, NUAK1, RPA3, RPA2, RPA1, TRIM47, AARSD1, PUS1, P3H1, RPRD1B, XPO5, OSGEP, NSUN2, NUSAP1, TTLL12, NUDT5, ARPC2, ACTR3, CUL1, TPP2, PFDN5, PFDN1, NRD1, PAN2, LATS1, gag, FMNL1, PAXIP1, IDH3G, CDV3, RHOA, LRRK2, ATXN10, SIAH2, FBXO25, ARRB2, ELAVL
Protein Size: 1030 - Molecular Weight
- 113 kDa
- Gene ID
- 4659
- NCBI Accession
- NM_002480, NP_002471
- UniProt
- O14974
- Pathways
- M Phase
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