FGF8 antibody (C-Term)

Catalog No. ABIN2774365

The Rabbit Polyclonal anti-FGF8 antibody is suitable to detect FGF8 in samples from Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig, Zebrafish (Danio rerio), Pig, Horse and Sheep. It has been validated for WB.

Quick Overview for FGF8 antibody (C-Term) (ABIN2774365)

Target: FGF8 (Fibroblast Growth Factor 8 (Androgen-Induced) (FGF8))

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig, Zebrafish (Danio rerio), Pig, Horse, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGF8 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FGF8 Antibody

Binding Specificity: C-Term

Purpose: FGF8 Antibody - C-terminal region

Sequence: EGWYMAFTRK GRPRKGSKTR QHQREVHFMK RLPRGHHTTE QSLRFEFLNY

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 75%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 75%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against FGF8. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63185-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for FGF8

Target: FGF8 (Fibroblast Growth Factor 8 (Androgen-Induced) (FGF8))

Alternative Name: FGF8

Background:

Background Information: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants.

Gene Name: Fibroblast growth factor 8 (androgen-induced)

Alternative Symbols: HH6, AIGF, KAL6, FGF-8, HBGF-8

Protein Name: Fibroblast growth factor 8

Molecular Weight: 22kDa

Gene ID: 2253

NCBI Accession: NP_006110

UniProt: P55075

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Dopaminergic Neurogenesis