KIR2DL5A antibody (C-Term)
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- Target See all KIR2DL5A Antibodies
- KIR2DL5A (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 5A (KIR2DL5A))
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Binding Specificity
- C-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This KIR2DL5A antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- QLDHCVFTQT KITSPSQRPK TPPTDTTMYM ELPNAKPRSL SPAHKHHSQA
- Predicted Reactivity
- Human: 100%
- Characteristics
- This is a rabbit polyclonal antibody against KIR2DL5A. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C-terminal region of Human KIR2DL5A
- Top Product
- Discover our top product KIR2DL5A Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 375 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- KIR2DL5A (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 5A (KIR2DL5A))
- Alternative Name
- KIR2DL5A (KIR2DL5A Products)
- Synonyms
- CD158F antibody, KIR2DL5 antibody, KIR2DL5.1 antibody, KIR2DL5.3 antibody, KIR2DL5B antibody, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A antibody, KIR2DL5A antibody
- Background
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Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules, thus, KIR proteins are thought to play an important role in regulation of the immune response.
Alias Symbols: CD158F, KIR2DL5, KIR2DL5.1, KIR2DL5.3
Protein Interaction Partner: PTPN6, PTPN11,
Protein Size: 375 - Molecular Weight
- 41 kDa
- Gene ID
- 57292
- NCBI Accession
- NM_020535, NP_065396
- UniProt
- Q8N109
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