DTX2 antibody (C-Term)

Catalog No. ABIN2774772

This Rabbit Polyclonal antibody specifically detects DTX2 in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Zebrafish (Danio rerio), Cow, Goat, Guinea Pig, Horse and Rabbit.

Quick Overview for DTX2 antibody (C-Term) (ABIN2774772)

Target: DTX2 (Deltex Homolog 2 (DTX2))

Reactivity: Human, Mouse, Rat, Dog, Zebrafish (Danio rerio), Cow, Goat, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DTX2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DTX2 Antibody

Binding Specificity: C-Term

Sequence: EDCGTILIVY SIPHGIQGPE HPNPGKPFTA RGFPRQCYLP DNAQGRKVLE

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against DTX2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human DTX2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 575 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DTX2

Target: DTX2 (Deltex Homolog 2 (DTX2))

Alternative Name: DTX2

Background: DTX2 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. DTX2 probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context and mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. It also functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Alias Symbols: KIAA1528, MGC71098, RNF58
Protein Interaction Partner: KRTAP26-1, RFX6, KLC3, GLYCTK, DTX2, RIMBP3, C1orf94, NCALD, PLEKHF2, TRIM54, EIF4ENIF1, ALKBH4, UBE2D4, HPCAL4, SPG21, SEC22A, SPAG8, STX12, NCS1, FAM168A, RBPMS, SEC23B, ABHD16A, VSNL1, SUMO1, UBE2D3, UBE2D1, UBC, TRIP6, QARS, HDC, GOLGA2, FHL2, ARNT2,
Protein Size: 575

Molecular Weight: 62 kDa

Gene ID: 113878

NCBI Accession: NM_001102596, NP_001096066

UniProt: Q6XM87

Pathways: Notch Signaling