ITCH antibody (N-Term)
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- Target See all ITCH Antibodies
- ITCH (Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))
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Binding Specificity
- N-Term
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Reactivity
- Human, Rat, Cow, Rabbit, Dog, Horse, Guinea Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ITCH antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- QLESEVVTNG ETTCSESASQ NDDGSRSKDE TRVSTNGSDD PEDAGAGENR
- Predicted Reactivity
- Cow: 86%, Dog: 92%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Rabbit: 93%, Rat: 86%
- Characteristics
- This is a rabbit polyclonal antibody against ITCH. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human ITCH
- Top Product
- Discover our top product ITCH Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 862 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- ITCH (Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))
- Alternative Name
- ITCH (ITCH Products)
- Synonyms
- AIF4 antibody, AIP4 antibody, NAPP1 antibody, dJ468O1.1 antibody, 6720481N21Rik antibody, 8030492O04Rik antibody, A130065M08 antibody, C230047C07Rik antibody, itchy E3 ubiquitin protein ligase antibody, itchy, E3 ubiquitin protein ligase antibody, ITCH antibody, Itch antibody
- Background
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Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like prot
Alias Symbols: AIF4, AIP4, NAPP1, dJ468O1.1
Protein Interaction Partner: GSN, UBE2L3, UBC, ITCH, WWOX, GGA3, UBE2D2, PTCH1, ATXN3, HTT, EGFR, SMAD6, DTX3L, CXCR4, LATS1, POLR2A, HNRNPL, EWSR1, RPAP2, CPSF7, RPAP3, UBAP2, PABPC1, DAZAP1, WBP2, SMARCE1, SMARCC2, SMARCC1, POLR2E, POLR2C, SPG20, HNRNPUL1, UBAP2L, URI1, ARID1A, SF1
Protein Size: 862 - Molecular Weight
- 99 kDa
- Gene ID
- 83737
- NCBI Accession
- NM_031483, NP_113671
- UniProt
- A9Z1X3
- Pathways
- Activation of Innate immune Response, CXCR4-mediated Signaling Events
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