ZYX antibody (Middle Region)

Catalog No. ABIN2775766

There is 1 publication for this product available. The Rabbit Polyclonal anti-ZYX antibody is suitable to detect ZYX in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse and Rabbit. It has been validated for WB.

Quick Overview for ZYX antibody (Middle Region) (ABIN2775766)

Target: ZYX (Zyxin (ZYX))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZYX antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ZYX Antibody

Binding Specificity: Middle Region

Purpose: ZYX Antibody - middle region

Sequence: GSPQPPSFTY AQQREKPRVQ EKQHPVPPPA QNQNQVRSPG APGPLTLKEV

Predicted Reactivity: Cow: 85%, Dog: 92%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 85%, Rabbit: 92%, Rat: 91%

Characteristics: This is a rabbit polyclonal antibody against ZYX. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ZYX

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP34387-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-ZYX antibody (ABIN2775766)

Moody, Grange, Ascione, Boothe, Bushnell, Hansen: "A zyxin head-tail interaction regulates zyxin-VASP complex formation." in: Biochemical and biophysical research communications, Vol. 378, Issue 3, pp. 625-8, (2008) (PubMed).

Target Details for ZYX

Target: ZYX (Zyxin (ZYX))

Alternative Name: ZYX

Background:

Background Information: Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles.

Gene Name: Zyxin

Alternative Symbols: ESP-2, HED-2

Protein Name: Zyxin

Molecular Weight: 61kDa

Gene ID: 7791

NCBI Accession: NP_003452

UniProt: Q15942