HDAC8 antibody (N-Term)

Catalog No. ABIN2775889

The Rabbit Polyclonal anti-HDAC8 antibody (ABIN2775889) specifically detects HDAC8 in WB. The antibody is reactive with Human, Rat, Mouse, Cow, Rabbit, Dog, Guinea Pig and Horse samples.

Quick Overview for HDAC8 antibody (N-Term) (ABIN2775889)

Target: HDAC8 (Histone Deacetylase 8 (HDAC8))

Reactivity: Human, Rat, Mouse, Cow, Rabbit, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC8 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HDAC8 Antibody

Binding Specificity: N-Term

Purpose: HDAC8 Antibody - N-terminal region

Sequence: MEEPEEPADS GQSLVPVYIY SPEYVSMCDS LAKIPKRASM VHSLIEAYAL

Predicted Reactivity: Cow: 86%, Dog: 86%, Guinea Pig: 91%, Horse: 93%, Human: 100%, Mouse: 79%, Rabbit: 79%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against HDAC8. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HDAC8

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP34586-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for HDAC8

Target: HDAC8 (Histone Deacetylase 8 (HDAC8))

Alternative Name: HDAC8

Background:

Background Information: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Histone deacetylase 8

Alternative Symbols: HD8, WTS, RPD3, CDA07, CDLS5, KDAC8, MRXS6, HDACL1

Protein Name: Histone deacetylase 8

Molecular Weight: 42kDa

Gene ID: 55869

NCBI Accession: NP_060956

UniProt: Q9BY41

Pathways: Cellular Glucan Metabolic Process