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TIA1 antibody (C-Term)

TIA1 Reactivity: Human, Mouse, Rat, Rabbit, Cow, Guinea Pig, Horse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2776556
  • Target See all TIA1 Antibodies
    TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))
    Binding Specificity
    • 15
    • 9
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 71
    • 35
    • 32
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Rabbit, Cow, Guinea Pig, Horse
    Host
    • 55
    • 15
    • 1
    Rabbit
    Clonality
    • 48
    • 23
    Polyclonal
    Conjugate
    • 33
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TIA1 antibody is un-conjugated
    Application
    • 41
    • 22
    • 17
    • 16
    • 14
    • 13
    • 11
    • 9
    • 6
    • 5
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    QAWNQQGFNQ TQSSAPWMGP NYGVQPPQGQ NGSMLPNQPS GYRVAGYETQ
    Predicted Reactivity
    Cow: 82%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 92%, Rabbit: 92%, Rat: 93%
    Characteristics
    This is a rabbit polyclonal antibody against TIA1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human TIA1
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    Discover our top product TIA1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 375 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))
    Alternative Name
    TIA1 (TIA1 Products)
    Synonyms
    tia1 antibody, 2310050N03Rik antibody, AI256674 antibody, TIA-1 antibody, mTIA-1 antibody, WDM antibody, TIAL1 antibody, TIAR antibody, tia-1 antibody, nucleolysin TIA-1 isoform p40 antibody, hypothetical protein antibody, nucleolysin TIAR antibody, nucleolysin tia-1 antibody, nucleolysin TIA-1 antibody, cytotoxic granule-associated RNA binding protein 1 antibody, TIA1 cytotoxic granule associated RNA binding protein antibody, TIA1 cytotoxic granule-associated RNA binding protein antibody, TIA1 cytotoxic granule-associated RNA binding protein L homeolog antibody, PTRG_10065 antibody, PGTG_08590 antibody, LOC5568274 antibody, CpipJ_CPIJ013665 antibody, VDBG_07004 antibody, MGYG_03339 antibody, Tsp_15456 antibody, tia1 antibody, Tia1 antibody, TIA1 antibody, tia1.L antibody
    Background
    TIA1 is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15- kDa protein that is thought to be derived from the carboxyl terminus of the 40- kDa product by proteolytic processing.The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15- kDa protein that is thought to be derived from the carboxyl terminus of the 40- kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature.
    Alias Symbols: TIA-1
    Protein Interaction Partner: NEDD8, BMI1, SOX2, VCAM1, ITGA4, FN1, FMNL1, WDR6, SRSF3, CAND1, DCUN1D1, COPS5, CUL1, CUL2, CUL3, CUL4A, CUL5, Rc3h1, UBC, RICTOR, FASTK,
    Protein Size: 375
    Molecular Weight
    42 kDa
    Gene ID
    7072
    NCBI Accession
    NM_022037, NP_071320
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