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Insulin Receptor antibody (Middle Region)

Name: Insulin Receptor antibody (Middle Region)
SKU: ABIN2776774
Price: 483.54 USD
Availability: InStock

INSR Reactivity: Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig, Rabbit, Pig WB, IHC Host: Rabbit Polyclonal unconjugated

WB Suggested Anti-INSR Antibody Titration: 0. (Insulin Receptor antibody (Middle Region))

Rabbit Anti-INSR Antibody Formalin Fixed Paraffin Embedded Tissue: Human Heart Tissue Observed Staining: Cytoplasm in cardiomyocytes Primary Antibody Concentration: 1:100 Other Working Concentrations: 1:600 Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0. (Insulin Receptor antibody (Middle Region))

IHC

Rabbit Anti-INSR Antibody Formalin Fixed Paraffin Embedded Tissue: Human heart Tissue Observed Staining: Cytoplasmic Primary Antibody Concentration: 1:100 Other Working Concentrations: 1:600 Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0. (Insulin Receptor antibody (Middle Region))

IHC

3 images

Catalog No. ABIN2776774

Datasheet as PDF

Target See all Insulin Receptor (INSR) Antibodies

Insulin Receptor (INSR)
Binding Specificity
16

14

13

10

8

8

8

5

5

5

4

4

4

4

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Middle Region
Reactivity
168

86

74

16

12

8

7

6

5

5

4

3

2

2

1

1

1

1

1

1

1

1
Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig, Rabbit, Pig
Host
156

26

2

1
Rabbit
Compatible Secondaries
Clonality
145

40
Polyclonal
Conjugate
118

15

14

5

4

4

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
This Insulin Receptor antibody is un-conjugated
Application
132

78

52

31

19

15

15

14

13

13

9

5

4

4

3

2

2

2

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC)

Sequence

ENNVVHLMWQ EPKEPNGLIV LYEVSYRRYG DEELHLCVSR KHFALERGCR

Predicted Reactivity

Cow: 93%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics

This is a rabbit polyclonal antibody against INSR. It was validated on Western Blot using a cell lysate as a positive control.

Purification

Affinity Purified

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human INSR

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INSR Reactivity: Human WB, IHC, IP, ICC Host: Mouse Monoclonal C19 unconjugated

anti-Insulin Receptor (INSR) (AA 1024-1298) antibody
INSR Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated

anti-Insulin Receptor (INSR) (AA 1027-1364) antibody
INSR Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated

anti-Insulin Receptor (INSR) (AA 1101-1372) antibody
INSR Reactivity: Mouse WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated

anti-Insulin Receptor (INSR) (AA 27-57), (N-Term) antibody
INSR Reactivity: Human, Mouse WB, IHC (p) Host: Rabbit Polyclonal RB1421 unconjugated

anti-Insulin Receptor (INSR) (C-Term) antibody
INSR Reactivity: Human, Mouse, Rat, Dog, Monkey, Horse, Cow, Guinea Pig, Rabbit, Pig, Chicken, Sheep, Hamster, Avian, Cat, Donkey, Goat WB Host: Goat Polyclonal unconjugated

anti-Insulin Receptor (INSR) (C-Term) antibody
KO Validated INSR Reactivity: Human WB, ICC, IF, IHC (p) Host: Rabbit Polyclonal unconjugated

anti-Insulin Receptor (INSR) (AA 1325-1358) antibody
INSR Reactivity: Mouse WB Host: Rabbit Polyclonal RB50340 unconjugated

anti-Insulin Receptor (INSR) (AA 1023-1298) antibody
INSR Reactivity: Human IHC, ELISA, IF Host: Rabbit Polyclonal unconjugated

anti-Insulin Receptor (INSR) (AA 51-150) antibody
INSR Reactivity: Human, Mouse, Rat WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated

Application Notes

Optimal working dilutions should be determined experimentally by the investigator.

Comment

Antigen size: 1382 AA

Restrictions

For Research Use only
Format

Liquid

Concentration

Lot specific

Buffer

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative

Sodium azide

Precaution of Use

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice

Avoid repeated freeze-thaw cycles.

Storage

-20 °C

Storage Comment

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target

Insulin Receptor (INSR)

Alternative Name

INSR (INSR Products)

Background

This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. INSR mediates the metabolic functions of insulin. INSR binding to insulin stimulates association of the receptor with downstream media
Alias Symbols: CD220, HHF5
Protein Interaction Partner: KRT31, UBC, ARRB2, MOK, Grb2, Hgf, DOK1, SH2B1, Stat5b, TEAD1, STAT5A, JAK2, JAK1, IRS1, IRF7, PLCG1, GRB10, Socs6, Socs1, SOCS3, SH2B2, HGS, INPPL1, Calmodulin, Mad2l1, KRT27, DOK5, DOK4, SNX6, SNX4, SNX2, ACP1, PTPN2, SYNCRIP, FRS2, PIK3R3, VAV3, ARHGAP
Protein Size: 1382

Molecular Weight

154 kDa

Gene ID

3643

NCBI Accession

NM_000208, NP_000199

UniProt

P06213

Pathways

NF-kappaB Signaling, RTK Signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity