Complement C2 antibody (Middle Region)

Catalog No. ABIN2776930

The Rabbit Polyclonal anti-Complement C2 antibody is suitable to detect Complement C2 in samples from Human, Rat, Mouse, Dog, Horse, Pig, Cow, Rabbit and Sheep. It has been validated for WB.

Quick Overview for Complement C2 antibody (Middle Region) (ABIN2776930)

Target: Complement C2

Reactivity: Human, Rat, Mouse, Dog, Horse, Pig, Cow, Rabbit, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Complement C2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Complement C2 Antibody

Binding Specificity: Middle Region

Purpose: C2 Antibody - middle region

Sequence: INQKRNDYLD IYAIGVGKLD VDWRELNELG SKKDGERHAF ILQDTKALHQ

Predicted Reactivity: Cow: 93%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Sheep: 93%

Characteristics: This is a rabbit polyclonal antibody against C2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human C2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8097850

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Complement C2

Target: Complement C2

Alternative Name: C2

Background:

Background Information: Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.

Gene Name: complement C2

Alternative Symbols: CO2, ARMD14

Protein Name: complement C2

Molecular Weight: 83kDa

Gene ID: 717

NCBI Accession: NP_000054

UniProt: P06681