Prostate Specific Antigen antibody (Middle Region)

Catalog No. ABIN2777044

Product Details anti-Prostate Specific Antigen Antibody

Target: Prostate Specific Antigen (PSA)

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Prostate Specific Antigen antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LRPGDDSSHD LMLLRLSEPA ELTDAVKVMD LPTQEPALGT TCYASGWGSI

Predicted Reactivity: Dog: 77%, Human: 100%, Mouse: 86%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against KLK3. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 261 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-Prostate Specific Antigen antibody (ABIN2777044)

Alzghoul, Hailat, Zivanovic, Que, Shah: "Measurement of serum prostate cancer markers using a nanopore thin film based optofluidic chip." in: Biosensors & bioelectronics, Vol. 77, pp. 491-8, (2015) (PubMed).

Target Details for Prostate Specific Antigen

Target: Prostate Specific Antigen (PSA)

Alternative Name: KLK3 (PSA Products)

Background: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms.
Alias Symbols: APS, KLK2A1, PSA, hK3
Protein Interaction Partner: ALB, PZP, SERPINA5, SERPINA1, SEMG2, SEMG1, PLG, PTHLH, IGFBP3, FN1, EPOR, SLPI, SERPINA3, A2M, POLR2A, AR, KAT5, RUVBL1, CTNNB1,
Protein Size: 261

Molecular Weight: 26 kDa

Gene ID: 354

NCBI Accession: NM_001648, NP_001639

UniProt: P07288

Pathways: Complement System