Progesterone Receptor antibody (N-Term)

Catalog No. ABIN2777173

The Rabbit Polyclonal anti-Progesterone Receptor antibody is suitable to detect Progesterone Receptor in samples from Human, Rat and Rabbit. It has been validated for WB.

Quick Overview for Progesterone Receptor antibody (N-Term) (ABIN2777173)

Target: Progesterone Receptor (PGR)

Reactivity: Human, Rat, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Progesterone Receptor antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Progesterone Receptor Antibody

Binding Specificity: N-Term

Purpose: PGR Antibody - N-terminal region

Sequence: LPRGLSPARQ LLLPASESPH WSGAPVKPSP QAAAVEVEEE DGSESEESAG

Predicted Reactivity: Human: 100%, Rabbit: 91%, Rat: 91%

Characteristics: This is a rabbit polyclonal antibody against PR. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human PGR

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP30886-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Progesterone Receptor

Target: Progesterone Receptor (PGR)

Alternative Name: PGR

Background:

Background Information: This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap.

Gene Name: progesterone receptor

Alternative Symbols: PR, NR3C3

Protein Name: progesterone receptor

Molecular Weight: 75kDa

Gene ID: 5241

NCBI Accession: NP_000917

UniProt: P06401

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Smooth Muscle Cell Migration