RGS17 antibody (Regulator of G-Protein Signaling 17) (C-Term)

Catalog No. ABIN2778238

Product Details anti-RGS17 Antibody

Target:

RGS17

Binding Specificity: C-Term

Reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RGS17 antibody is un-conjugated

Application: Western Blotting (WB)

Blocking Peptide: Blocking peptide for this product available: ABIN2184821

Sequence: NRNLLDPNPH MYEDAQLQIY TLMHRDSFPR FLNSQIYKSF VESTAGSSSE

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against RGS17. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human RGS17

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RGS17

Target:

RGS17

Alternative Name: RGS17 (RGS17 Antibody Abstract)

Synonyms: RGS17, zgc:92802, MGC179306, RGS-17, RGSZ2, hRGS17, 6430507P11Rik, Rgsz2, regulator of G protein signaling 17, regulator of G-protein signaling 17, RGS17, Rgs17, rgs17

Background: This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.
Alias Symbols: RGS-17, RGSZ2, hRGS17
Protein Interaction Partner: LCE3C, LCE2A, LCE4A, TBC1D16, DHX37, NUFIP2, PTGER3, OTX1, RPL10A, SMCP, HOXA1, GNAI3, GNAI1, AQP1, ADRB2, RABEP1, RBBP8, UBC, OSTM1,
Protein Size: 210

Molecular Weight: 23 kDa

Gene ID: 26575

NCBI Accession: NM_012419, NP_036551

UniProt: Q9UGC6

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling