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PRMT2 antibody (N-Term)

PRMT2 Reactivity: Human, Rat WB, ChIP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2778662
  • Target See all PRMT2 Antibodies
    PRMT2 (Protein Arginine Methyltransferase 2 (PRMT2))
    Binding Specificity
    • 12
    • 9
    • 8
    • 8
    • 2
    • 2
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 58
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat
    Host
    • 52
    • 5
    • 1
    Rabbit
    Clonality
    • 54
    • 4
    Polyclonal
    Conjugate
    • 31
    • 5
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PRMT2 antibody is un-conjugated
    Application
    • 50
    • 31
    • 20
    • 7
    • 5
    • 2
    • 2
    • 1
    Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)
    Sequence
    ERAGCCGYIP ANHVGKHVDE YDPEDTWQDE EYFGSYGTLK LHLEMLADQP
    Predicted Reactivity
    Human: 100%, Rat: 79%
    Characteristics
    This is a rabbit polyclonal antibody against PRMT2. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human PRMT2
    Top Product
    Discover our top product PRMT2 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 433 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Zhong, Cao, Liu, Liu, Wang, Liu, Chen, Yang, Zhang, Wu, Ding, Hong, Xiao, Zu, Wen: "Nuclear loss of protein arginine N-methyltransferase 2 in breast carcinoma is associated with tumor grade and overexpression of cyclin D1 protein." in: Oncogene, Vol. 33, Issue 48, pp. 5546-58, (2014) (PubMed).

    Meyer, Wolf, Obendorf: "PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor." in: The Journal of steroid biochemistry and molecular biology, Vol. 107, Issue 1-2, pp. 1-14, (2007) (PubMed).

  • Target
    PRMT2 (Protein Arginine Methyltransferase 2 (PRMT2))
    Alternative Name
    PRMT2 (PRMT2 Products)
    Synonyms
    PRMT2 antibody, DKFZp459N1919 antibody, HRMT1L1 antibody, Hrmt1l1 antibody, AI504737 antibody, protein arginine methyltransferase 2 antibody, protein arginine methyltransferase 2 L homeolog antibody, protein arginine N-methyltransferase 2 antibody, PRMT2 antibody, Prmt2 antibody, prmt2.L antibody
    Background
    The protein arginine methyltransferases (PRMTs) include a family of proteins with related putative methyltransferase domains that modify chromatin and regulate cellular transcription. PRMT2 inhibits NF-kappaB-dependent transcription and promotes apoptosis and it exerts this effect by blocking nuclear export of IkappaB-alpha through a leptomycin-sensitive pathway, increasing nuclear IkappaB-alpha and decreasing NF-kappaB DNA binding. PRMT2 also rendered cells susceptible to apoptosis by cytokines or cytotoxic drugs, likely due to its effects on NF-kappaB.
    Alias Symbols: HRMT1L1, MGC111373
    Protein Interaction Partner: FIP1L1, SPAG8, RIPK2, BAG6, RB1, HNRNPA1, E2F1, UBC, PSMB3, HHV8GK18_gp81, CPSF7, DMRTB1, HNRNPUL1, PRMT2, THRB, PGR, NCOA6, NCOA1, ESR2, RXRA, PRRC2A, ESR1, PPARG, RARA,
    Protein Size: 433
    Molecular Weight
    49 kDa
    Gene ID
    3275
    NCBI Accession
    NM_001535, NP_001526
    UniProt
    P55345
    Pathways
    Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding
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