TRF2 antibody (C-Term)

Catalog No. ABIN309587

The Rabbit Polyclonal anti-TRF2 antibody has been validated for WB. It is suitable to detect TRF2 in samples from Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse and Rabbit.

Quick Overview for TRF2 antibody (C-Term) (ABIN309587)

Target: TRF2 (TERF2) (Telomeric Repeat Binding Factor 2 (TERF2))

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRF2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TRF2 Antibody

Binding Specificity: C-Term

Sequence: TVEESEWVKA GVQKYGEGNW AAISKNYPFV NRTAVMIKDR WRTMKRLGMN

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against TERF2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TERF2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 500 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TRF2

Target: TRF2 (TERF2) (Telomeric Repeat Binding Factor 2 (TERF2))

Alternative Name: TERF2

Background: TERF2 is a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: TRBF2, TRF2
Protein Interaction Partner: UBC, TERF2IP, TINF2, EP300, SLX4, RPA3, RPA2, RPA1, BMI1, DCLRE1B, BLM, ATM, VCP, NBN, MRE11A, HMGA1, RAD50, TOP3A, HSP90AA1, TEP1, SF3B2, TOP2A, TFAP4, OCM2, NUMA1, NCL, NASP, HMGN2, HMGN1, HMGB1, H2AFX, XRCC6, CTBP1, ASS1, APEX1, ANXA5, DDX39A, HMGN3, D
Protein Size: 500

Molecular Weight: 55 kDa

Gene ID: 7014

NCBI Accession: NM_005652, NP_005643

UniProt: Q15554

Pathways: Cell Division Cycle, Telomere Maintenance