MAP3K8 antibody (C-Term)
-
- Target See all MAP3K8 Antibodies
- MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))
-
Binding Specificity
- C-Term
-
Reactivity
- Human, Rat, Mouse, Cow, Horse, Dog, Rabbit, Guinea Pig
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This MAP3K8 antibody is un-conjugated
-
Application
- Western Blotting (WB)
- Sequence
- PRCQSLDSAL LERKRLLSRK ELELPENIAD SSCTGSTEES EMLKRQRSLY
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 77%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against MAP3K8. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human MAP3K8
- Top Product
- Discover our top product MAP3K8 Primary Antibody
-
-
- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
-
Antigen size: 467 AA
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- Target
- MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))
- Alternative Name
- MAP3K8 (MAP3K8 Products)
- Synonyms
- MAP3K8 antibody, COT antibody, EST antibody, ESTF antibody, MEKK8 antibody, TPL2 antibody, Tpl-2 antibody, c-COT antibody, Cot antibody, Cot/Tpl2 antibody, Est antibody, Estf antibody, Tpl2 antibody, D17TPL2 antibody, mitogen-activated protein kinase kinase kinase 8 antibody, MAP3K8 antibody, map3k8 antibody, Map3k8 antibody
- Background
-
MAP3K8 is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity.
Alias Symbols: COT, EST, ESTF, TPL2, MEKK8, Tpl-2, c-COT
Protein Interaction Partner: RELA, MAP2K1, RIPK1, NFKB1, ACY3, STIP1, HSP90AA1, TAB2, TRAF6, TRAF2, CD40, TNIP2, Nedd4, MAP3K14, MAP2K4, BMPR2, CHUK, REL, AKT1, NFKB2, KSR2,
Protein Size: 467 - Molecular Weight
- 53 kDa
- Gene ID
- 1326
- NCBI Accession
- NM_005204, NP_005195
- UniProt
- P41279
- Pathways
- PI3K-Akt Signaling, TCR Signaling
-