IRF5 antibody (Middle Region)

Catalog No. ABIN2779405

Cited in 1 publication. The Rabbit Polyclonal anti-IRF5 antibody (ABIN2779405) specifically detects IRF5 in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Pig, Rabbit, Horse, Dog, Guinea Pig and Zebrafish (Danio rerio) samples.

Quick Overview for IRF5 antibody (Middle Region) (ABIN2779405)

Target: IRF5 (Interferon Regulatory Factor 5 (IRF5))

Reactivity: Human, Mouse, Rat, Cow, Pig, Rabbit, Horse, Dog, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRF5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IRF5 Antibody

Binding Specificity: Middle Region

Purpose: IRF5 Antibody - middle region

Sequence: IFFCFGEEWP DRKPREKKLI TVQVVPVAAR LLLEMFSGEL SWSADSIRLQ

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against IRF5. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human IRF5

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP31994-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-IRF5 antibody (ABIN2779405)

Coletta, Cullington, Clark, Cleland: "Clinical trials update from European Society of Cardiology meeting 2008: TIME-CHF, BACH, BEAUTIFUL, GISSI-HF, and HOME-HF." in: European journal of heart failure, Vol. 10, Issue 12, pp. 1264-7, (2008) (PubMed).

Target Details for IRF5

Target: IRF5 (Interferon Regulatory Factor 5 (IRF5))

Alternative Name: IRF5

Background:

Background Information: IRF5 is a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative splice variants encoding different isoforms exist. This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative splice variants encoding different isoforms exist.

Gene Name: Interferon regulatory factor 5

Alternative Symbols: SLEB10

Protein Name: Interferon regulatory factor 5

Molecular Weight: 56kDa

Gene ID: 3663

NCBI Accession: NP_116032

UniProt: Q13568

Pathways: TLR Signaling, Autophagy