Paired Box 3 antibody (Middle Region)

Catalog No. ABIN2779649

The Rabbit Polyclonal anti-Paired Box 3 antibody (ABIN2779649) specifically detects Paired Box 3 in WB. The antibody is reactive with Human, Mouse, Rat, Dog, Cow, Horse, Guinea Pig, Rabbit and Goat samples.

Quick Overview for Paired Box 3 antibody (Middle Region) (ABIN2779649)

Target: Paired Box 3 (PAX3)

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Guinea Pig, Rabbit, Goat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Paired Box 3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Paired Box 3 Antibody

Binding Specificity: Middle Region

Purpose: PAX3 Antibody - middle region

Sequence: KGEEEEADLE RKEAEESEKK AKHSIDGILS ERASAPQSDE GSDIDSEPDL

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PAX3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PAX3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP32446-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Paired Box 3

Target: Paired Box 3 (PAX3)

Alternative Name: PAX3

Background:

Background Information: PAX3 is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2,13)(q35,q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma.

Gene Name: Paired box 3

Alternative Symbols: WS1, WS3, CDHS, HUP2

Protein Name: Paired box protein Pax-3

Molecular Weight: 45kDa

Gene ID: 5077

NCBI Accession: NP_852126

UniProt: Q86UQ3

Pathways: Sensory Perception of Sound, Tube Formation