p53 antibody (C-Term)

Catalog No. ABIN2779979

This Rabbit Polyclonal antibody specifically detects p53 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Pig, Rabbit, Horse, Sheep and Guinea Pig.

Quick Overview for p53 antibody (C-Term) (ABIN2779979)

Target: p53 (TP53) (Tumor Protein P53 (TP53))

Reactivity: Human, Mouse, Rat, Cow, Dog, Pig, Rabbit, Horse, Sheep, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This p53 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-p53 Antibody

Binding Specificity: C-Term

Sequence: TEEENFRKKE VLCPELPPGS AKRALPTCTS ASPPQKKKPL DGEYFTLKIR

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 92%, Rat: 100%, Sheep: 100%

Characteristics: This is a rabbit polyclonal antibody against TRP53. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 390 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for p53

Target: p53 (TP53) (Tumor Protein P53 (TP53))

Alternative Name: TRP53

Background: Trp53 is a protein found in elevated levels in a great variety of transformed cells
Alias Symbols: bbl, bfy, bhy, p44, p53, Tp53
Protein Interaction Partner: PRKAA1, Rnf128, Ndn, Herc2, Rchy1, Rps26, Rpl11, Cdkn2a, Bcl2l1, Daxx, Mdm2, Wwox, Mapk8, Smyd1, Ubc, Twist1, Pten, Bard1, Ep300, Sumo1, Trp73, Trp63, Strm, Nqo1, Mif, Hspa1b, Hipk2, Axin1, Zbtb7c, Topors, Gsk3b, Foxp3, Huwe1, Park7, Ccng1, NUMB, Skil, Cu
Protein Size: 390

Molecular Weight: 43 kDa

Gene ID: 22059

NCBI Accession: NM_011640, NP_035770

UniProt: P02340

Pathways: p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, Warburg Effect